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As each individual absorbs nicotine at different rates, there is a range of other factors that play an important role, including: How much nicotine you have consumed recently Your age profile (over 65 years old takes longer to clear nicotine from their system) How your kidney operates one that functions badly takes more time to remove nicotine and cotinine Genetics as different races metabolise nicotine at different rates Any medication you may be taking Diet Gender whether youre male or female matters, with women having a better chance of clearing quicker due to hormone levels The substances then break down further via the kidneys and leave the body through urine